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ACD antibody

CAT: 0710-FNab00078Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00078Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
Synonyms
Adrenocortical dysplasia protein homolog|POT1 and TIN2-interacting protein|ACD|PIP1|PTOP|TINT1|TPP1
Gene ID
65057
UniProt
Q96AP0
Host
Rabbit
Reactivity
Human
Immunogen
Adrenocortical dysplasia homolog (Mouse)
Target
ACD
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
58 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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