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AATF antibody

CAT: 0710-FNab00025Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00025Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Synonyms
Protein AATF|Apoptosis-antagonizing transcription factor|Rb-binding protein Che-1|AATF|CHE1|DED
Gene ID
26574
UniProt
Q9NY61
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Apoptosis antagonizing transcription factor
Target
AATF
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
63 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF

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