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ALOX15B antibody

CAT: 0710-FNab00005Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00005Size:100 µg
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Background
In humans, there are 6 functional lipoxygenases genes. Two of them encode for arachidonic acid 12-lipoxygenating (ALOX12, ALOX12B) and two for 15-lipoxygenating enzymes (ALOX15, ALOX15B) . ALOX15B has been described as the most abundant 15-lipoxygenating enzyme species in human carotid atherosclerotic lesions and to be associated with cerebrovascular symptoms. (PMID:24373925) . ALOX15B has 4 isoforms produced by alternative splicing with the MW of 76, 67, 69 and 73 kDa.
Synonyms
Polyunsaturated fatty acid lipoxygenase ALOX15B|15-lipoxygenase 2 (15-LOX-2) |Arachidonate 15-lipoxygenase B (15-LOX-B) |Arachidonate 15-lipoxygenase type II|Linoleate 13-lipoxygenase 15-LOb|ALOX15B
Gene ID
247
UniProt
O15296
Host
Rabbit
Reactivity
Human
Immunogen
Arachidonate 15-lipoxygenase, type B
Target
ALOX15B
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC,IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
76 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF
Immunogen Sequence
1-200aa

UniProtKB · O15296

Polyunsaturated fatty acid lipoxygenase ALOX15B

LX15B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15296
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ALOX15B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
D3DTR2, Q8IYQ2, Q8TEV3, Q8TEV4, Q8TEV5, Q8TEV6, Q9UKM4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumIronLipid-bindingMetal-binding

Cellular component

Cell junctionCell membraneCytoplasmCytoskeletonMembraneNucleus

Molecular function

DioxygenaseOxidoreductase

Biological process

Lipid metabolism

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