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ALOX5 antibody

CAT: 0710-FNab00007Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00007Size:100 µg
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Background
ALOX5 (arachidonate 5-lipoxygenase) is also named as LOG5, 5-LO and belongs to the lipoxygenase family. It catalyzes the first step in leukotriene biosynthesis, and plays a role in inflammatory processes. It is a 78 kDa iron-containing enzyme that translocates from the cytosol to associate with FLAP, and converts arachidonate in two steps into the unstable intermediate LTA4. It is essential for cysteinyl-leukotriene (cys-LT) production, critical mediators in asthma (PMID:12911785) .
Synonyms
Polyunsaturated fatty acid 5-lipoxygenase|Arachidonate 5-lipoxygenase (5-LO, 5-lipoxygenase) |ALOX5|LOG5
UniProt
P09917
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Arachidonate 5-lipoxygenase
Target
ALOX5
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IF, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IF: 1:20-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
68-78 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IF, WB
Immunogen Sequence
1-300aa

UniProtKB · P09917

Polyunsaturated fatty acid 5-lipoxygenase

LOX5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09917
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ALOX5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.13.11.-
Processing
—
Secondary accessions
B7ZLS0, E5FPY5, E5FPY7, E5FPY8, Q5JQ14
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumIronMetal-binding

Cellular component

CytoplasmMembraneNucleus

Molecular function

DioxygenaseHydrolaseOxidoreductase

Biological process

Leukotriene biosynthesisLipid metabolism

PTM

Phosphoprotein

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