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Aschantin

CAT: 0804-HY-N10754Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N10754Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aschantin, a bisepoxylignan, can be isolated from Magnolia biondii. Aschantin has antiplasmodial, Ca2+-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. Aschantin is a mTOR kinase inhibitor. Aschantin is also an inhibitor of Cytochrome P450 and UGT enzyme[1][2].
CAS Number
13060-15-6
UNSPSC
12352005
Target
Cytochrome P450; mTOR
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/aschantin.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OC)C(OC)=CC([C@@H]2[C@]3([H])[C@@](CO2)([H])[C@@H](C4=CC=C(OCO5)C5=C4)OC3)=C1
Molecular Formula
C22H24O7
Molecular Weight
400.42
References & Citations
[1]Lee CJ, et al. Aschantin targeting on the kinase domain of mammalian target of rapamycin suppresses epidermal growth factor-induced neoplastic cell transformation. Carcinogenesis. 2015 Oct;36 (10) :1223-34.|[2]Kwon SS, et al. Inhibitory Effects of Aschantin on Cytochrome P450 and Uridine 5'-diphospho-glucuronosyltransferase Enzyme Activities in Human Liver Microsomes. Molecules. 2016 Apr 27;21 (5) :554.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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