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Atraric acid

CAT: 0804-HY-N2908-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2908-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases[1][2].
CAS Number
4707-47-5
Product Name Alternative
Methyl atrarate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Androgen Receptor; NF-κB; NO Synthase; p38 MAPK
Type
Natural Products
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/atraric-acid.html
Concentration
10mM
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC)C1=C(C)C=C(O)C(C)=C1O
Molecular Formula
C10H12O4
Molecular Weight
196.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Roell D, Baniahmad A. The natural compounds atraric acid and N-butylbenzene-sulfonamide as antagonists of the human androgen receptor and inhibitors of prostate cancer cell growth. Mol Cell Endocrinol. 2011 Jan 30;332 (1-2) :1-8.|[2]Papaioannou M, et al. The natural compound atraric acid is an antagonist of the human androgen receptor inhibiting cellular invasiveness and prostate cancer cell growth. J Cell Mol Med. 2009 Aug;13 (8B) :2210-2223.
Shipping Conditions
Room Temperature
Storage Conditions
RT, stored under nitrogen
Scientific Category
Natural Products
Clinical Information
No Development Reported

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