DAP Kinase 1 Recombinant Mouse Monoclonal Antibody [12B2-R]

DAP Kinase 1 Recombinant Mouse Monoclonal Antibody [12B2-R]

• Description: Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene. Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. In melanocytic cells DAPK1 gene expression may be regulated by MITF. Depletion of DAPK1 results in inhibition of tumor cell count and volume growth in cellular and animal models of triple receptor-negative breast cancer, from individuals with p53-mutant cancers. This has not been demonstrated in actual patients.
• Product Name Alternative: DAK1 antibody DAP K1 antibody DAP kinase 1 antibody DAPK 1 antibody DAPK antibody DAPK1 antibody DAPK1_HUMAN antibody Death Associated Protein Kinase 1 antibody Death-associated protein kinase 1 antibody DKFZp781I035 antibody
• Abbreviation: DAPK1, DAPK
• CAS Number: 9000-83-3
• Swiss Prot: P53355 Human
• Cellular Locus: Cytoplasm, cytoskeleton.
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Recombinant protein within human DAP Kinase 1 aa 451-700 / 1,430.
• Isotype: IgG1
• Clone: 12B2-R
• Conjugation: Non-conjugated
• Type: Recombinant Mouse monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: A549 cell lysate, TF-1 cell lysate, HepG2 cell lysate, human brain tissue lysate, human lung carcinoma tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:2,000 ;IHC-P: 1:2,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 160 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes