Salmeterol
CAT:
804-HY-14302-03
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Salmeterol
- CAS Number: 89365-50-4
- UNSPSC Description: Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].
- Target Antigen: Adrenergic Receptor
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Neuronal Signaling
- Field of Research: Endocrinology; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/Salmeterol.html
- Solubility: DMSO : ≥ 100 mg/mL
- Smiles: OC1=CC=C(C(O)CNCCCCCCOCCCCC2=CC=CC=C2)C=C1CO
- Molecular Weight: 415.57
- References & Citations: [1]Panayiotis A Procopiou, et al. The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group. Bioorg Med Chem. 2011 Oct 15;19(20):6026-32.|[2]Malcolm Johnson. Effects of beta2-agonists on resident and infiltrating inflammatory cells. J Allergy Clin Immunol. 2002 Dec;110(6 Suppl):S282-90.|[3]Zhiyuan Wang, et al. Efficacy of salmeterol and formoterol combination treatment in mice with chronic obstructive pulmonary disease. Exp Ther Med. 2018 Feb;15(2):1538-1545.Cell Rep. 2019 Dec 3;29(10):2929-2935.e4|Drug Test Anal. 2020 Aug 27.|J Pharm Anal. 2024 Jan 4.|J Pharmaceut Biomed. 2020, 113870.|Nat Commun. 2020 Sep 25;11(1):4857.|Neuron. 2024 Jul 25:S0896-6273(24)00494-X.|Neurobiol Dis. 2020 Jul;140:104874.
- Shipping Conditions: Room Temperature
- Clinical Information: Launched