Ani9

• Description :

  Ani9 is an ANO1 inhibitor, with an IC50 of 77 nM. Ani9 can inhibit smooth muscle contractions in mice and is applicable in research related to diseases such as tumors[1][2][3].

• UNSPSC :

  12352005

• Target :

  Chloride Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ani9.html

• Purity :

  99.12

• Solubility :

  DMSO : ≥ 125 mg/mL

• Smiles :

  O=C(COC1=CC=C(C=C1C)Cl)N/N=C/C2=CC=CC=C2OC

• Molecular Formula :

  C17H17ClN2O3

• Molecular Weight :

  332.78

• References & Citations :

  [1]Seo Y, et al. Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2. PLoS One. 2016 May 24;11 (5) :e0155771. |[2]Seo Y, et al. Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors. Eur J Med Chem. 2018 Dec 5;160:245-255.|[3]Naoki Kawata, et al. Increased TMEM16A-Mediated Ca2+-Activated Cl− Currents in Portal Vein Smooth Muscle Cells of Caveolin 1-Deficient Mice. Biol. Pharm. Bull. 45, 1692–1698 (2022) .

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [356102-14-2]