Ani9

CAT: 0804-HY-119981-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-119981-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Ani9 is an ANO1 inhibitor, with an IC50 of 77 nM. Ani9 can inhibit smooth muscle contractions in mice and is applicable in research related to diseases such as tumors[1][2][3].

CAS Number

356102-14-2

UNSPSC

12352005

Target

Chloride Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ani9.html

Purity

99.12

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C(COC1=CC=C(C=C1C)Cl)N/N=C/C2=CC=CC=C2OC

Molecular Formula

C17H17ClN2O3

Molecular Weight

332.78

References & Citations

[1]Seo Y, et al. Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2. PLoS One. 2016 May 24;11 (5) :e0155771. |[2]Seo Y, et al. Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors. Eur J Med Chem. 2018 Dec 5;160:245-255.|[3]Naoki Kawata, et al. Increased TMEM16A-Mediated Ca2+-Activated Cl− Currents in Portal Vein Smooth Muscle Cells of Caveolin 1-Deficient Mice. Biol. Pharm. Bull. 45, 1692–1698 (2022) .

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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