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CBiPES

CAT: 0804-HY-107505A-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107505A-06Size:100 mg
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Description
CBiPES is a potent mGlu2 positive allosteric modulator with an EC50 value of 92.8 nM. CBiPES attenuates stress-induced hyperthermia and Phencyclidine-induced hyperlocomotor activity. CBiPES can be used for research of neurological diseases, such as Parkinson's disease (PD) [1][2].
CAS Number
353235-01-5
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cbipes.html
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCS(N(C1=CC(C2=CC=C(C#N)C=C2)=CC=C1)CC3=CN=CC=C3)(=O)=O
Molecular Formula
C21H19N3O2S
Molecular Weight
377.46
References & Citations
[1]Johnson MP, et al. Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model (s) . Psychopharmacology (Berl) . 2005 Apr;179 (1) :271-83.|[2]Frouni I, et al. Effect of the mGlu2 positive allosteric modulator CBiPES on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset. J Neural Transm (Vienna) . 2021 Jan;128 (1) :73-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Cbipes
CAS Number353235-01-5
PubChem CID9864510
IUPAC NameN-[3-(4-cyanophenyl)phenyl]-N-(pyridin-3-ylmethyl)ethanesulfonamide
Molecular FormulaC21H19N3O2S
Molecular Weight377.5
XLogP3.2
Topological Polar Surface Area82.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count27
Formal Charge0
Complexity613
SMILES
CCS(=O)(=O)N(CC1=CN=CC=C1)C2=CC=CC(=C2)C3=CC=C(C=C3)C#N
InChI
InChI=1S/C21H19N3O2S/c1-2-27(25,26)24(16-18-5-4-12-23-15-18)21-7-3-6-20(13-21)19-10-8-17(14-22)9-11-19/h3-13,15H,2,16H2,1H3
InChIKey
HDVYXILCBYGKGU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cbipes
CAS: 353235-01-5
CID: 9864510
Formula: C21H19N3O2S
MW: 377.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight377.5
XLogP33.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass377.11979803
Monoisotopic Mass377.11979803
Topological Polar Surface Area82.4 Ų
Heavy Atom Count27
Formal Charge0
Complexity613
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A15811-500CBiPES HCl 500mg
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A15811-10CBiPES hydrochloride 10mg

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