Poly-L-lysine (hydrochloride)

• UNSPSC Description:

  Poly-L-lysine hydrochloride is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Poly-L-lysine hydrochloride is a strong-attraction regulator that promotes liquid-liquid phase separation (LLPS) at low concentrations but suppresses LLPS at high concentrations. Antibacterial cationic peptide.[1].

• Target Antigen:

  Bacterial

• Type:

  Oligonucleotides

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/poly-l-lysine-hydrochloride.html

• Solubility:

  H2O : 50 mg/mL (ultrasonic;warming)

• Smiles:

  CN[C@@H](CCCC[NH3+])C(C)=O.[n].[Cl-].[n]

• Molecular Weight:

  30000-50000

• References & Citations:

  [1]Archishman Ghosh, et al. Three archetypical classes of macromolecular regulators of protein liquid-liquid phase separation. Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19474-19483.|[2]Liang Guo, et al. pH-induced structural transition during complexation and precipitation of sodium caseinate and ε-Poly-l-lysine. Int J Biol Macromol. 2020 Jul 1;154:644-653.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  26124-78-7