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D-Histidine (Standard)

CAT: 0804-HY-W012572R-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W012572R-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-Histidine (Standard) is the analytical standard of D-Histidine. This product is intended for research and analytical applications. D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu2+)[2][3].
CAS Number
351-50-8
UNSPSC
12352005
Target
Bacterial; Mitochondrial Metabolism; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/d-histidine-standard.html
Smiles
OC([C@H](N)CC1=CN=CN1)=O
Molecular Formula
C6H9N3O2
Molecular Weight
155.15
References & Citations
[1]Bou Zeidan M, et al. L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One. 2014 Nov 4;9 (11) :e112141.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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