Hyodeoxycholic acid

Hyodeoxycholic acid

• CAS Number: 83-49-8
• UNSPSC Description: Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.
• Target Antigen: Endogenous Metabolite; G protein-coupled Bile Acid Receptor 1
• Type: Natural Products
• Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/Hyodeoxycholic_acid.html
• Purity: 99.87
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL
• Smiles: C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
• Molecular Weight: 392.57
• References & Citations: [1]Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51(6):1831-41.|[2]Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep;27(9):3805-17.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: Launched