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Hyodeoxycholic acid

CAT: 0804-HY-N0169-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0169-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.
CAS Number
83-49-8
Product Name Alternative
HDCA
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Endogenous Metabolite; G protein-coupled Bile Acid Receptor 1
Type
Natural Products
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Hyodeoxycholic_acid.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Formula
C24H40O4
Molecular Weight
392.57
Precautions
H315, H319, H335
References & Citations
[1]Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51 (6) :1831-41.|[2]Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep;27 (9) :3805-17.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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