Rugonersen

• Description :

  Rugonersen (RG6091; RO7248824) is a locked-nucleic acid (LNA) - modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch[1][2].

• CAS Number :

  [2591587-57-2]

• Product Name Alternative :

  RG6091; RO7248824

• UNSPSC :

  12352208

• Target :

  E1/E2/E3 Enzyme

• Type :

  Oligonucleotides

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/rugonersen.html

• Purity :

  98.50

• Solubility :

  H2O : ≥ 100 mg/mL

• Smiles :

  [Rugonersen]

• Molecular Formula :

  C204H254N63O109P19S19

• Molecular Weight :

  6530.30

• References & Citations :

  [1]World Health Organization · 2021: WHO Drug Information.|[2]R Jagasia, et al. Angelman syndrome patient neuron screen identifies a potent and selective clinical ASO targeting UBE3A-ATS with long lasting effect in cynomolgus monkey. bioRxiv, 2022-06-12.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Oligonucleotides

• Clinical Information :

  Phase 1