All-trans-retinal

• Description :

  All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH) . All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis[1].

• CAS Number :

  [116-31-4]

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315

• Target :

  Apoptosis; Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/All-trans-retinal.html

• Purity :

  99.76

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C\C=O

• Molecular Formula :

  C20H28O

• Molecular Weight :

  284.44

• Precautions :

  H302, H315

• References & Citations :

  [1]Sawada O, et al. All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis. Exp Eye Res. 2014 Jun;123:27-36.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite