All-trans-retinal

• UNSPSC Description:

  All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis[1].

• Target Antigen:

  Apoptosis; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/All-trans-retinal.html

• Purity:

  99.76

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C\C=O

• Molecular Weight:

  284.44

• References & Citations:

  [1]Sawada O, et al. All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis. Exp Eye Res. 2014 Jun;123:27-36.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  116-31-4