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Ro18-5362

CAT: 0804-HY-U00193Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-U00193Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ro18-5362 is the less active proagent of Ro 18-5364. Even at concentrations as high as 0.1 mM Ro 18-5362 fails to affect significantly (H++K+) -ATPase activity and associated proton translocation.
CAS Number
[101387-97-7]
UNSPSC
12352005
Target
Na+/K+ ATPase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Ro18-5362.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C)(C)C2=C(C=C3NC(SCC4=NC=CC(OC)=C4C)=NC3=C2)C1(C)C
Molecular Formula
C22H25N3O2S
Molecular Weight
395.52
References & Citations
[1]Sigrist-Nelson K, et al. Ro 18-5364, a potent new inhibitor of the gastric (H+ + K+) -ATPase. Eur J Biochem. 1987 Jul 15;166 (2) :453-9.|[2]Sigrist-Nelson K, et al. Gastric (H+ + K+) -ATPase: modulation of the inhibitory properties of the novel potent antisecretagogue Ro 18-5364 by sulfhydryl reagents and nucleotides. FEBS Lett. 1986 Mar 3;197 (1-2) :187-91.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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