CCP peptide

• Description :

  CCP peptide is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA) [1][2].

• UNSPSC :

  12352209

• Target :

  Others

• Type :

  Peptides

• Related Pathways :

  Others

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ccp-peptide.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C([C@@H]1NC(=O)[C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)N)=O)CCC(N)=O)=O)CSSC[C@@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)CO)=O)=O)CO)=O)CCCNC(=N)N)=O)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)[H])C3=CN=CN3

• Molecular Formula :

  C87H145N41O32S2

• Molecular Weight :

  2341.47

• References & Citations :

  [1]Puszczewicz M, et al. Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis. Arch Med Sci. 2011 Apr;7 (2) :189-94.|[2]Söderlin MK, et al. Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity. Scand J Rheumatol. 2004;33 (3) :185-8.|[3]Schellekens GA, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000 Jan;43 (1) :155-63.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [277748-59-1]