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Endothelin-3, human, mouse, rabbit, rat

CAT: 0804-HY-P0204-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0204-01Size:500 µg
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Description
Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.
CAS Number
117399-93-6
Product Name Alternative
Endothelin 3 (Rat, Human)
UNSPSC
12352209
Hazard Statement
H300+H330
Target
G Protein-coupled Receptor Kinase (GRK)
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Endothelin-3,_human,_mouse,_rabbit,_rat.html
Purity
97.58
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C([C@H]1NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@]2([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@](NC([C@@H](NC([C@@](CSSC2)([H])NC([C@](NC([C@H](CSSC1)N)=O)([H])[C@H](O)C)=O)=O)CC3=CC=CC=C3)=O)([H])[C@H](O)C)=O)CC4=CC=C(C=C4)O)=O)CCCCN)=O)CC(O)=O)=O)CCCCN)=O)CCC(O)=O)=O)=O)C(C)C)=O)CC5=CC=C(C=C5)O)=O)CC6=CC=C(C=C6)O)=O)N[C@@H](CC7=CN=CN7)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC8=CNC9=CC=CC=C89)=O)=O)=O)=O)=O
Molecular Formula
C121H168N26O33S4
Molecular Weight
2643.04
Precautions
H300+H330
References & Citations
[1]Skovsted GF, et al. Endothelin-1 and Endothelin-3 Regulate Endothelin Receptor Expression in Rat Coronary Arteries. Basic Clin Pharmacol Toxicol. 2015 Nov;117 (5) :297-305.|[2]Gazquez E, et al. Endothelin-3 stimulates cell adhesion and cooperates with β1-integrins during enteric nervous system ontogenesis. Sci Rep. 2016 Dec 1;6:37877. doi: 10.1038/srep37877.|[3]Sato A, et al. Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor. Inflamm Res. 2013 Apr;62 (4) :417-24.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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