(Arg) 9 (TFA)

• Description :

  (Arg) 9 (Nona-L-arginine) TFA is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg) 9 TFA has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model[1][2].

• Product Name Alternative :

  Nona-L-arginine (TFA) ; Peptide R9 (TFA)

• UNSPSC :

  12352209

• Target :

  Ser/Thr Protease

• Type :

  Peptides

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/arg-9-tfa.html

• Purity :

  99.57

• Solubility :

  H2O : ≥ 100 mg/mL

• Smiles :

  O=C(O)C(F)(F)F.N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C54H110N36O10.xC2HF3O2

• Molecular Weight :

  1423.69 (free acid)

• References & Citations :

  [1]Meloni BP, et, al. The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014 Mar;34 (2) :173-81.|[2]Meloni BP, et, al. Poly-arginine and arginine-rich peptides are neuroprotective in stroke models. J Cereb Blood Flow Metab. 2015 Jun;35 (6) :993-1004.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  Phase 2

• CAS Number :

  [2283335-13-5]