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Nonactin

CAT: 0804-HY-N6790-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6790-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity[1][2][3][4].
CAS Number
6833-84-7
Product Name Alternative
Ammonium ionophore I
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Antibiotic; Apoptosis; Bacterial; HSP; Influenza Virus; Mitochondrial Metabolism; Oxidative Phosphorylation; Potassium Channel
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/nonactin.html
Purity
99.0
Solubility
DMF : 50 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 6.67 mg/mL (ultrasonic)
Smiles
O=C(O[C@H](C)C[C@@]1([H])CC[C@@](O1)([H])[C@H](C)C(O[C@@H](C)C[C@]2([H])CC[C@](O2)([H])[C@@H](C)C(O[C@H](C)C[C@@]3([H])CC[C@@](O3)([H])[C@@H]4C)=O)=O)[C@H](C)[C@@](O5)([H])CC[C@@]5([H])C[C@H](C)OC4=O
Molecular Formula
C40H64O12
Molecular Weight
736.93
Precautions
H315, H319, H335
References & Citations
[1]Martínez-Haya B, et al. On the ionophoric selectivity of nonactin and related macrotetrolide derivatives. Phys Chem Chem Phys. 2017 Jan 4;19 (2) :1288-1297.|[2]Shikata Y, et al. Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. Cancer Sci. 2017 Apr;108 (4) :772-784.|[3]Barazi HO, et al. Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation. Cancer Res. 2002 Mar 1;62 (5) :1541-8.|[4]Boykova I, et al. Strain Streptomyces sp. P-56 Produces Nonactin and Possesses Insecticidal, Acaricidal, Antimicrobial and Plant Growth-Promoting Traits. Microorganisms. 2023 Mar 16;11 (3) :764.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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TBI2090-5MGNonactin, Monovalent cation ionophore (K+ and NH4+)
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