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Nonactin

CAT: 0400-SIH-372-25MGSize: 25 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-372-25MGSize:25 mg
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Background
Nonactin also known as Polynanctin, Werramycin A is a member of the family of cyclic ionophores. It has a high selectivity for ammonium ions and for this reason is also known as “ammonium ionophore”. It was first isolated by Corbaz et al. in 1955 from bacterial strains (1). To understand the required stereochemistry for an efficient bacterial and ion binding, various isothermal calorimetric measurements were performed with K+, Na+ and NH4+. Nonactin is active against a range of gram positive organisms and has a high selectivity for K+ (2).
Description
Ammonium ionophore
CAS Number
6833-84-7
Product Name Alternative
(1R,2R,5R,7R,10S,11S,14S,16S,19R,20¬R,23R,25R,28S,29S,32S,34S) -2,5,11,14,20,23,29,32-O¬ctamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo-[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,3¬0-tetrone
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience
Purity
>98% (TLC)
Weight
0.025
Format
White to off-White solid
Solubility
Soluble in DMSO, methanol, ethanol (10 mM), dichloromethane and ethyl acetate. Insoluble in water.
Molecular Formula
C40H64O12
Molecular Weight
736.93
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Corbaz R., et al. (1955) Helvetica Chimica Acta 38(60): 1445-48. 2. Kushe B., Smith A., McGuirl M., Priestley N., (2009) J Am Chem Soc 131(47): 17555-165.

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