Jatrorrhizine

CAT: 0804-HY-N0749Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N0749Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Jatrorrhizine is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities[1]. Jatrorrhizine is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE[2]. Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters[3].
CAS Number
[3621-38-3]
UNSPSC
12352005
Hazard Statement
H302-H319-H332-H372-H400
Target
5-HT Receptor; Bacterial; Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jatrorrhizine.html
Smiles
COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(O)C=C4CC3)C=C2C=C1
Molecular Formula
C20H20NO4+
Molecular Weight
338.38
Precautions
P260-P261-P264-P270-P271-P273-P280-P304+P340-P305+P351+P338-P330-P391-P501
References & Citations
[1] Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49 (10) :1237-1243.|[2]Xiaofei Jiang, et al. Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase. Research Article Volume 2017|[3]C W Wright, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63 (12) :1638-40.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE
Citation 01
Arch Microbiol. 2025 Jun 17;207 (8) :177.|Molecules. 2024 May 14.

Alternative Products

CatalogName
SM4148-100mgJatrorrhizine
MBS3611522-01Jatrorrhizine chloride
M39511-01Jatrorrhizine hydroxide
TB0285Jatrorrhizine Hydrochloride
TRC-J210913-5MGJatrorrhizine Iodide

Popular Products