Tacrine (hydrochloride) (hydrate)

Tacrine (hydrochloride) (hydrate)

• CAS Number: 206658-92-6
• UNSPSC Description: Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.
• Target Antigen: Cholinesterase (ChE)
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Tacrine_hydrochloride_hydrate.html
• Purity: 99.98
• Solubility: DMSO : 32 mg/mL (ultrasonic;warming)|H2O : 100 mg/mL (ultrasonic)
• Smiles: NC1=C(CCCC2)C2=NC3=CC=CC=C31.[H]Cl.[H]O[H].[x].[x]
• References & Citations: [1]Ahmed M, et al. Inhibition of two different cholinesterases by tacrine. Chem Biol Interact. 2006 Aug 25;162(2):165-71.|[2]Grasing K, et al. Enduring effects of tacrine on cocaine-reinforced behavior: Analysis by conditioned-place preference, temporal separation from drug reward, and reinstatement. Pharmacol Res. 2015 Jul;97:40-7.Front Neurosci. 2020 May 28:14:458.|Bioorg Chem. 2023 Nov 29, 107010.|Cell Death Dis. 2022 Jan 10;13(1):48.|Eur J Med Chem. 2023 Dec 21, 116071.|J Enzyme Inhib Med Chem. 2023 Dec;38(1):2192439.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Launched