Tacrine (hydrochloride) (hydrate) (Standard)

• UNSPSC Description:

  Tacrine (hydrochloride) (hydrate) (Standard) is the analytical standard of Tacrine (hydrochloride) (hydrate). This product is intended for research and analytical applications. Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.

• Target Antigen:

  Cholinesterase (ChE)

• Type:

  Reference Standards

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/tacrine-hydrochloride-hydrate-standard.html

• Smiles:

  NC1=C(CCCC2)C2=NC3=CC=CC=C31.[H]Cl.[H]O[H].[x].[x]

• References & Citations:

  [1]Ahmed M, et al. Inhibition of two different cholinesterases by tacrine. Chem Biol Interact. 2006 Aug 25;162(2):165-71.|[2]Grasing K, et al. Enduring effects of tacrine on cocaine-reinforced behavior: Analysis by conditioned-place preference, temporal separation from drug reward, and reinstatement. Pharmacol Res. 2015 Jul;97:40-7.

• Shipping Conditions:

  Room temperature

• CAS Number:

  206658-92-6