Cardiogenol C (hydrochloride)

Cardiogenol C (hydrochloride)

• CAS Number: 1049741-55-0
• UNSPSC Description: Cardiogenol C hydrochloride is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM)[1]. Cardiogenol C hydrochloride also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C hydrochloride is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models[2].
• Target Antigen: Wnt; β-catenin
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/Cardiogenol-C-hydrochloride.html
• Purity: 99.79
• Solubility: DMSO : ≥ 59 mg/mL|H2O : 2 mg/mL (ultrasonic)
• Smiles: [H]Cl.COC1=CC=C(NC2=NC=CC(NCCO)=N2)C=C1
• Molecular Weight: 296.75
• References & Citations: [1]Wu X, et al. Small molecules that induce cardiomyogenesis in embryonic stem cells.J Am Chem Soc. 2004 Feb 18;126(6):1590-1.|[2]Mike AK, et al. Small molecule cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Cell Physiol Biochem. 2014;33(1):205-21.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported