Cardiogenol C

• Description:

  Cardiogenol C is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM) [1]. Cardiogenol C also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models[2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Wnt; β-catenin

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cardiogenol-c.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=C(NC2=NC=CC(NCCO)=N2)C=C1

• Molecular Formula:

  C13H16N4O2

• Molecular Weight:

  260.29

• Precautions:

  P264-P270-P330-P501

• References & Citations:

  [1]Wu X, et al. Small molecules that induce cardiomyogenesis in embryonic stem cells.J Am Chem Soc. 2004 Feb 18;126 (6) :1590-1.|[2]Mike AK, et al. Small molecule cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Cell Physiol Biochem. 2014;33 (1) :205-21.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [671225-39-1]