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Cardiogenol C

CAT: 0804-HY-12319Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12319Size:1 Each
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Description
Cardiogenol C is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM) [1]. Cardiogenol C also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models[2].
CAS Number
671225-39-1
UNSPSC
12352005
Hazard Statement
H302
Target
Wnt; β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cardiogenol-c.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(NC2=NC=CC(NCCO)=N2)C=C1
Molecular Formula
C13H16N4O2
Molecular Weight
260.29
Precautions
P264-P270-P330-P501
References & Citations
[1]Wu X, et al. Small molecules that induce cardiomyogenesis in embryonic stem cells.J Am Chem Soc. 2004 Feb 18;126 (6) :1590-1.|[2]Mike AK, et al. Small molecule cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Cell Physiol Biochem. 2014;33 (1) :205-21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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T2161-01Cardiogenol C
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