S-Adenosyl-L-methionine

S-Adenosyl-L-methionine

• CAS Number: 29908-03-0
• UNSPSC Description: S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].
• Target Antigen: Apoptosis; Endogenous Metabolite
• Type: Natural Products
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cancer; Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Ademetionine.html
• Purity: 98.0
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 43 mg/mL
• Smiles: O[C@H]1[C@](O[C@@H]([C@H]1O)C[S+](C)CC[C@H](N)C([O-])=O)([H])N2C3=NC=NC(N)=C3N=C2
• Molecular Weight: 398.44
• References & Citations: [1]G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.|[2]Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.|[3]Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42.|[4]Mosca L, et al. Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 2020 May;56(5):1212-1224. |[5]Ham MS, et al. S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells. Mol Clin Oncol. 2013 Mar;1(2):373-378. |[6]Ornoy A, et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol Teratol. 2019 Jan-Feb;71:64-74. |[7]Dhediya RM, et al. Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats. Epilepsy Behav. 2016 Aug;61:153-157. Biochem Pharmacol. 2023 Dec 6:219:115967.|bioRxiv. 2023 Jun 1.|Epigenetics Chromatin. 2021 Dec 4;14(1):52.|Int Immunopharmacol. 2021 Mar 22;95:107545.|J Agric Food Chem. 2021 Jul 30.|Research Square Preprint. 2020 Aug.|Research Square Preprint. 2021 Jun.|J Cell Physiol. 2024 Oct 6:e31452.|Molecules. 2023 Apr 11, 28(8), 3375.|J Pharm Biomed Anal. 2024 Jan 20, 115991.|Pharmacol Res. 2024 Sep 16:107420.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: Launched