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Mafenide

CAT: 0804-HY-B0614-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0614-01Size:5 mg
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Description
Mafenide is an effective sulfonamide-type antimicrobial agent used for burn wounds. Mafenide shows activity against both Gram-positive and Gram-negative organisms, including Pseudomonas aeruginosa, via inhibition of nucleotide synthesis[1][2].
CAS Number
138-39-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mafenide.html
Purity
99.96
Solubility
DMSO : 30.3 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(CN)C=C1)(N)=O
Molecular Formula
C7H10N2O2S
Molecular Weight
186.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Haynes, B.W., Jr., Mafenide acetate in burn treatment. N Engl J Med, 1971. 284 (23) : p. 1324.|[2]Ashkan Afshari, et al. The Effective Duration of Antimicrobial Activity of Mafenide Acetate After Reconstitution. J Burn Care Res. 2018 Aug 17;39 (5) :736-738.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

Chemical Information

Mafenide

Mafenide is an aromatic amine.

CAS Number138-39-6
PubChem CID3998
IUPAC Name4-(aminomethyl)benzenesulfonamide
Molecular FormulaC7H10N2O2S
Molecular Weight186.23
XLogP-0.7
Topological Polar Surface Area94.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count12
Formal Charge0
Complexity224
SMILES
C1=CC(=CC=C1CN)S(=O)(=O)N
InChI
InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)
InChIKey
TYMRLRRVMHJFTF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mafenide
CAS: 138-39-6
CID: 3998
Formula: C7H10N2O2S
MW: 186.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight186.23
XLogP3-0.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass186.04629874
Monoisotopic Mass186.04629874
Topological Polar Surface Area94.6 Ų
Heavy Atom Count12
Formal Charge0
Complexity224
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
RG-M021101-01Mafenide
B3480-1000Mafenide Acetate
T1026-01Mafenide hydrochloride

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