Lincomycin (hydrochloride)

• Description:

  Lincomycin hydrochloride is the salt form of the antibiotic lincomycin. Lincomycin can affect the synthesis of protein, RNA and DNA in the mycelium of the lincomycin-producing organism Act. Roseolus. Lincomycin inhibits protein synthesis in gram-positive and - to a lower degree - also in gram-negative bacteria. Lincomycin binds to the 50S subunits of bacterial ribosomes and act on aminoacyl-tRNA binding and the transpeptidation reaction[1][2][3].

• Product Name Alternative:

  U10149A

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Antibiotic; Bacterial; DNA/RNA Synthesis

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/lincomycin-hydrochloride.html

• Purity:

  99.29

• Solubility:

  H2O : 100 mg/mL (ultrasonic)

• Smiles:

  C[C@@H](O)[C@@]([C@@]([C@@H]([C@H](O)[C@H]1O)O)([H])O[C@@H]1SC)([H])NC([C@@H]2C[C@@H](CCC)CN2C)=O.Cl

• Molecular Formula:

  C18H35ClN2O6S

• Molecular Weight:

  443.00

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Griaznova, N.S., et al., [Effect of lincomycin and other protein synthesis inhibitors on the metabolism of Actinomyces roseolus, a producer of lincomycin]. Antibiotiki, 1980. 25 (4) : p. 250-6.|[2]Hummel, H., W. Piepersberg, and A. Bock, Analysis of lincomycin resistance mutations in Escherichia coli. Mol Gen Genet, 1979. 169 (3) : p. 345-7.|[3]Champney, W.S. and C.L. Tober, Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics. Curr Microbiol, 2000. 41 (2) : p. 126-35.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Citation 01:

  Chemosphere. 2019 Jun:225:378-387.|Microb Biotechnol. 2021 Nov;14 (6) :2538-2551.|Microbiol Spectr. 2025 Aug 29:e0059025.

• CAS Number:

  [859-18-7]