Lincomycin (hydrochloride)

CAT: 0804-HY-B0417A-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0417A-01Size:100 mg
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Description
Lincomycin hydrochloride is the salt form of the antibiotic lincomycin. Lincomycin can affect the synthesis of protein, RNA and DNA in the mycelium of the lincomycin-producing organism Act. Roseolus. Lincomycin inhibits protein synthesis in gram-positive and - to a lower degree - also in gram-negative bacteria. Lincomycin binds to the 50S subunits of bacterial ribosomes and act on aminoacyl-tRNA binding and the transpeptidation reaction[1][2][3].
CAS Number
[859-18-7]
Product Name Alternative
U10149A
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Antibiotic; Bacterial; DNA/RNA Synthesis
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/lincomycin-hydrochloride.html
Purity
99.29
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
C[C@@H](O)[C@@]([C@@]([C@@H]([C@H](O)[C@H]1O)O)([H])O[C@@H]1SC)([H])NC([C@@H]2C[C@@H](CCC)CN2C)=O.Cl
Molecular Formula
C18H35ClN2O6S
Molecular Weight
443.00
Precautions
H315, H319, H335
References & Citations
[1]Griaznova, N.S., et al., [Effect of lincomycin and other protein synthesis inhibitors on the metabolism of Actinomyces roseolus, a producer of lincomycin]. Antibiotiki, 1980. 25 (4) : p. 250-6.|[2]Hummel, H., W. Piepersberg, and A. Bock, Analysis of lincomycin resistance mutations in Escherichia coli. Mol Gen Genet, 1979. 169 (3) : p. 345-7.|[3]Champney, W.S. and C.L. Tober, Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics. Curr Microbiol, 2000. 41 (2) : p. 126-35.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
Launched
Citation 01
Chemosphere. 2019 Jun:225:378-387.|Microb Biotechnol. 2021 Nov;14 (6) :2538-2551.|Microbiol Spectr. 2025 Aug 29:e0059025.

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