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Fenoprofen (Calcium)

CAT: 0804-HY-B0288ASize: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0288ASize:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fenoprofen (LILLY-53858) Calcium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX) . Fenoprofen Calcium is a melanocortin receptors (MCRs) positive allosteric modulator (PAM) . Fenoprofen Calcium also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis[1][2].
CAS Number
34597-40-5
Product Name Alternative
LILLY-53858 (Calcium)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
COX; ERK; Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Fenoprofen-Calcium.html
Solubility
10 mM in DMSO
Smiles
CC(C(O)=O)C1=CC(OC2=CC=CC=C2)=CC=C1.[0.5Ca]
Molecular Formula
C15H14O3.1/2Ca
Molecular Weight
262.31
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Yuan XC, et al. Fenoprofen-An Old Drug Rediscovered as a Biased Allosteric Enhancer for Melanocortin Receptors. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1066-1074. |[2]Montero-Melendez T, et al. Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cell Mol Life Sci. 2017 Apr;74 (7) :1335-1345.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX

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