Fenoprofen (Calcium)

• Description :

  Fenoprofen (LILLY-53858) Calcium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX) . Fenoprofen Calcium is a melanocortin receptors (MCRs) positive allosteric modulator (PAM) . Fenoprofen Calcium also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis[1][2].

• Product Name Alternative :

  LILLY-53858 (Calcium)

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  COX; ERK; Melanocortin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/Fenoprofen-Calcium.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C(O)=O)C1=CC(OC2=CC=CC=C2)=CC=C1.[0.5Ca]

• Molecular Formula :

  C15H14O3.1/2Ca

• Molecular Weight :

  262.31

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Yuan XC, et al. Fenoprofen-An Old Drug Rediscovered as a Biased Allosteric Enhancer for Melanocortin Receptors. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1066-1074. |[2]Montero-Melendez T, et al. Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cell Mol Life Sci. 2017 Apr;74 (7) :1335-1345.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  COX

• CAS Number :

  [34597-40-5]