Fenoprofen

CAT: 0804-HY-B1456A-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1456A-01Size:100 mg
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Description
Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX) . Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM) . Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis[1][2].
CAS Number
[29679-58-1]
Product Name Alternative
LILLY-53858
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX; ERK; Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fenoprofen.html
Purity
99.70
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C(C)C1=CC=CC(OC2=CC=CC=C2)=C1
Molecular Formula
C15H14O3
Molecular Weight
242.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Montero-Melendez T, et al. Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cell Mol Life Sci. 2017 Apr;74 (7) :1335-1345.|[2]Xiao-Chen Yuan, et al. Fenoprofen-An Old Drug Rediscovered as a Biased Allosteric Enhancer for Melanocortin Receptors. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1066-1074.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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