Lapatinib-d4-1

Lapatinib-d4-1

• CAS Number: 1184264-15-0
• UNSPSC Description: Lapatinib-d4-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].
• Target Antigen: Autophagy; EGFR; Ferroptosis; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Autophagy;JAK/STAT Signaling;Others;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Solubility: 10 mM in DMSO
• Smiles: CS(CCNCC1=CC=C(O1)C2=CC(C(NC3=CC(Cl)=C(C=C3)OCC4=C([2H])C(F)=C([2H])C([2H])=C4[2H])=NC=N5)=C5C=C2)(=O)=O
• Molecular Weight: 585.08
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported