Products for Research Use Only
RegisterLogin

I3MT-3

CAT: 0804-HY-128206-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-128206-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM) . I3MT-3 is inactive for other H2S/sulfane sulfur-producing enzymes. I3MT-3 targets a persulfurated cysteine residue located in the active site of 3MST[1].
CAS Number
459420-09-8
Product Name Alternative
HMPSNE
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Hippo (MST)
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/i3mt-3.html
Concentration
10mM
Purity
99.76
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1NC(SCC(C2=C3C=CC=CC3=CC=C2)=O)=NC(C)=C1
Molecular Formula
C17H14N2O2S
Molecular Weight
310.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Kenjiro Hanaoka, et al. Discovery and Mechanistic Characterization of Selective Inhibitors of H 2 S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide. Sci Rep. 2017 Jan 12;7:40227|[2]Fiona Augsburger, et al. Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells. Biomolecules. 2020 Mar 13;10 (3) :447.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-W081226-013,3,3-Trifluoropropionyl chloride
HY-W127810-013,3',3''-Nitrilotripropionic Acid
HY-W4403031,1',3,3,3',3'-Hexamethylindotricarbocyanine (perchlorate)
HY-W1146693- (3- (3-Ethoxy-3-oxopropoxy) propoxy) propanoicacid
HY-D1075-011,1',3,3,3',3'-Hexamethylindodicarbocyanine (iodide)
HY-79034-013,3-Dimethylcyclohexanone
HY-131942SFTX-3.3
HY-178928KV1.3-IN-3
HY-176547FGFR2/3-IN-3
HY-14611-013,3'-Difluorobenzaldazine

Alternative Products

CatalogName
M24410-01I3MT-3
PC68253,3,3-Trifluoropropyl 3,3,3-trifluoropropanoate
QMC01729-013- (3,3,3-Trifluoropropoxy) pyridine
JFC42829-013- (3,3,3-Trifluoropropyl) aniline
sc-2604333- (3,3,3-Trifluoropropyl) heptamethyltrisiloxane
PDC53711-013- (3,3,3-Trifluoropropoxy) piperidine
NU-456S3',3',3'-cAAG
1607393,3,3-Trimethoxypropanenitrile
JMB17199-013,3,3-Trifluoropropanehydrazide
sc-2611293,3,3-Trifluoropropionitrile

Popular Products