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IKD-8344

CAT: 0804-HY-N8280Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N8280Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties. It is cytotoxic to L5178Y murine leukemia cells (IC50=0.54 ng/ml) .1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC=6.25 μg/mL) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.
CAS Number
129046-69-1
UNSPSC
12352005
Target
Fungal
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ikd-8344.html
Smiles
C[C@@H]([C@@](CC1)([H])O[C@@H]1C)[C@@](OC([C@H]([C@@]2([H])O[C@@H](CC([C@@H]([C@](CC3)([H])O[C@]3([H])C4)C)=O)CC2)C)=O)([H])C[C@@]5([H])O[C@]([C@H](C(C[C@@H]6O[C@@]([C@@H](C(O[C@@]4([H])[C@H]([C@@](CC7)([H])O[C@@H]7C)C)=O)C)([H])CC6)=O)C)([H])CC5
Molecular Formula
C48H76O12
Molecular Weight
845.11
References & Citations
[1]Minami, et al. Structure of a novel macrodiolide antibiotic IKD-8344. Tetrahedron Lett. 33 (48), 7373-7376 (1992) .
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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