CIM-834

• Description :

  CIM-834 is an orally active and selective inhibitor targeting the coronavirus membrane protein (M protein), which potently blocks viral assembly against SARS-CoV-2 and SARS-CoV. CIM-834 binds to the short form of the M protein (Mshort) in a non-covalent manner, stabilizing Mshort and preventing its conformational switch to the long form (Mlong) required for virion assembly, thereby inhibiting viral particle formation. CIM-834 is promising for research of COVID-19 and other coronavirus infections[1].

• UNSPSC :

  12352005

• Target :

  SARS-CoV; Virus Protease

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Purity :

  98.71

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1=NC(N2CCC(N(C)C3=CC(C(NCCN4CCCC4)=O)=CN=N3)CC2)=NC(C)=C1CC(C)C

• Molecular Formula :

  C27H42N8O

• Molecular Weight :

  494.68

• References & Citations :

  [1]Laporte M, et al. A coronavirus assembly inhibitor that targets the viral membrane protein. Nature. 2025 Apr;640 (8058) :514-523.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported