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ARG1 antibody

CAT: 0710-FNab10829Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10829Size:100 µg
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Background
Arginase-1 (Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology and a marker of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation (PMID:12098359) and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins (PMID: 20071539) .It can exsit as a homotrimer (PMID:16141327) and it has 3 isoforms produced by alternative splicing.Defects in ARG1 are the cause of argininemia (ARGIN) . Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control. (PMID:27117406) .
Synonyms
Arginase-1|Liver-type arginase|Type I arginase|ARG1
Gene ID
383
UniProt
P05089
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Arginase, liver
Target
ARG1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IF, WB
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
25-40 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IF, WB

UniProtKB · P05089

Arginase-1

ARGI1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05089
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ARG1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.5.3.1
Processing
—
Secondary accessions
A6NEA0, Q5JWT5, Q5JWT6, Q8TE72, Q9BS50
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityArginine metabolismImmunityInnate immunityUrea cycle

Coding sequence diversity

Alternative splicing

Cellular component

Cytoplasm

Disease

Disease variant

Molecular function

Hydrolase

Ligand

ManganeseMetal-binding

PTM

Phosphoprotein

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