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Anamorelin (Fumarate)

CAT: 0804-HY-14734BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14734BSize:1 Each
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Description
Anamorelin (RC-1291) Fumarate is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin Fumarate can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin Fumarate can be used in the research of anorexia and cancer cachexia[1][2].
CAS Number
339539-92-3
Product Name Alternative
RC-1291 (Fumarate) ; ONO-7643 (Fumarate)
UNSPSC
12352005
Target
GHSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/anamorelin-fumarate.html
Solubility
10 mM in DMSO
Smiles
[H][C@](CC1=CNC2=CC=CC=C21)(NC(C(C)(C)N)=O)C(N3CCC[C@@](C(N(C)N(C)C)=O)(CC4=CC=CC=C4)C3)=O.O=C(O)/C=C/C(O)=O
Molecular Formula
C35H46N6O7
Molecular Weight
662.78
References & Citations
[1]Pietra C, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexiasyndrome: preclinical profile. J Cachexia Sarcopenia Muscle. 2014 Dec;5 (4) :329-37.|[2]Northrup R, et al. Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model. Support Care Cancer. 2013 Sep;21 (9) :2409-15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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