Anamorelin

CAT: 0804-HY-14734-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-14734-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Anamorelin (RC-1291) is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin can be used in the research of anorexia and cancer cachexia[1][2].

CAS Number

249921-19-5

Product Name Alternative

RC-1291; ONO-7643

UNSPSC

12352005

Hazard Statement

H301

Target

GHSR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Anamorelin.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H][C@](CC1=CNC2=CC=CC=C21)(NC(C(C)(C)N)=O)C(N3CCC[C@@](C(N(C)N(C)C)=O)(CC4=CC=CC=C4)C3)=O

Molecular Formula

C31H42N6O3

Molecular Weight

546.70

Precautions

H301

References & Citations

[1]Pietra C, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexiasyndrome: preclinical profile. J Cachexia Sarcopenia Muscle. 2014 Dec;5 (4) :329-37.|[2]Northrup R, et al. Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model. Support Care Cancer. 2013 Sep;21 (9) :2409-15.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

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