CCT241533

• UNSPSC Description:

  CCT241533 is a potent and selective ATP competitive inhibitor of CHK2 with an IC50 of 3 nM and Ki of 1.16 nM[1].

• Target Antigen:

  Checkpoint Kinase (Chk)

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cct241533.html

• Purity:

  98.58

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(OC)C=C(C(N[C@H]2[C@H](C(C)(C)O)CNC2)=NC(C3=C(O)C=CC(F)=C3)=N4)C4=C1

• Molecular Weight:

  442.48

• References & Citations:

  [1]Anderson VE, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71(2):463-72.|[2]Caldwell JJ, et al. Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54(2):580-90.Cell Death Differ. 2021 Jul;28(7):2060-2082.|Int J Mol Sci. 2022, 23(20), 12290.|J Chem Inf Model. 2017 Nov 27;57(11):2699-2706. |J Cell Biol. 2021 Feb 1;220(2):e201911025.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1262849-73-9