Products for Research Use Only
RegisterLogin

CCT241736

CAT: 0804-HY-18161-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-18161-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CCT241736 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor, which inhibits Aurora kinases (Aurora-A Kd, 7.5 nM, IC50, 38 nM; Aurora-B Kd, 48 nM), FLT3 kinase (Kd, 6.2 nM), and FLT3 mutants including FLT3-ITD (Kd, 38 nM) and FLT3 (D835Y) (Kd, 14 nM) .
CAS Number
1402709-93-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aurora Kinase; FLT3
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CCT241736.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=NN(C)C=C1C2=NC3=C(N4CCN(CC5=CC=C(Cl)C=C5)CC4)C(Cl)=CN=C3N2
Molecular Formula
C22H23Cl2N7
Molecular Weight
456.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Bavetsias V, et al. Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia. J Med Chem. 2012 Oct 25;55 (20) :8721-34.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Aurora B

Related Products

CatalogName
HY-101026-01CCT251236
HY-18958-01CCT245737
HY-14715CCT241533
HY-101026RCCT251236 (Standard)
HY-110331CCT241533 (dihydrochloride)
HY-18958A(S) -CCT245737
HY-14715B-01CCT241533 (hydrochloride)

Alternative Products

CatalogName
T4428-01CCT241736
A21097-50CCT241736 50mg
A21097-100CCT241736 100mg
A21097-25CCT241736 25mg
A21097-10CCT241736 10mg
A21097-5CCT241736 5mg
A21097-10mM-DCCT241736 10mM * 1mL in DMSO

Popular Products