Products for Research Use Only
RegisterLogin

BC1618

CAT: 0804-HY-134656-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-134656-02Size:10 mM - 1 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation) . BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity[1].
CAS Number
2222094-18-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AMPK; E1/E2/E3 Enzyme; Mitophagy
Type
Reference compound
Related Pathways
Autophagy; Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bc1618.html
Concentration
10mM
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(COC1=CC=C(C(F)(F)F)C=C1)CN(CC2=CC=CC=C2)CC3=CC=CC=C3
Molecular Formula
C24H24F3NO2
Molecular Weight
415.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Yuan Liu, et al. A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance. Nat Chem Biol. 2021 Mar;17 (3) :298-306.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1-(Dibenzylamino)-3-(4-(trifluoromethyl)phenoxy)propan-2-ol
CAS Number2222094-18-8
PubChem CID134417552
IUPAC Name1-(dibenzylamino)-3-[4-(trifluoromethyl)phenoxy]propan-2-ol
Molecular FormulaC24H24F3NO2
Molecular Weight415.4
XLogP5.2
Topological Polar Surface Area32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Heavy Atom Count30
Formal Charge0
Complexity448
SMILES
C1=CC=C(C=C1)CN(CC2=CC=CC=C2)CC(COC3=CC=C(C=C3)C(F)(F)F)O
InChI
InChI=1S/C24H24F3NO2/c25-24(26,27)21-11-13-23(14-12-21)30-18-22(29)17-28(15-19-7-3-1-4-8-19)16-20-9-5-2-6-10-20/h1-14,22,29H,15-18H2
InChIKey
LGTYABNNHILKHF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(Dibenzylamino)-3-(4-(trifluoromethyl)phenoxy)propan-2-ol
CAS: 2222094-18-8
CID: 134417552
Formula: C24H24F3NO2
MW: 415.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight415.4
XLogP35.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Exact Mass415.17591349
Monoisotopic Mass415.17591349
Topological Polar Surface Area32.7 Ų
Heavy Atom Count30
Formal Charge0
Complexity448
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-108618-01BC11-38

Alternative Products

CatalogName
BA3692-5BC1618

Popular Products