Creatine (monohydrate)

• Description:

  Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain[1].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Akt; Endogenous Metabolite; PI3K

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease; PI3K/Akt/mTOR

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/creatine-monohydrate.html

• Purity:

  99.98

• Solubility:

  H2O : 16.67 mg/mL (ultrasonic)

• Smiles:

  O=C(O)CN(C(N)=N)C.[H]O[H]

• Molecular Formula:

  C4H11N3O3

• Molecular Weight:

  149.15

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Nouioua S, et al. Creatine deficiency syndrome. A treatable myopathy due to arginine-glycine amidinotransferase (AGAT) deficiency. Neuromuscul Disord. 2013 Aug;23 (8) :670-4.|[2]Gerber I, et al., Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures. Eur Cell Mater. 2005 Jul 15;10:8-22.|[3]Guidi C, et al., Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA. Biochim Biophys Acta. 2008 Jan;1780 (1) :16-26.|[4]Cunha MP, et al., Antidepressant-like effect of creatine in mice involves dopaminergic activation. J Psychopharmacol. 2012 Nov;26 (11) :1489-501.|[5]ARRUDA I F S, et al. Histological effects of Creatine monohydrate supplementation on muscle tissue in Wistar rats[J]. Modern Medicine, 2023, 30 (2) .

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  Human Endogenous Metabolite; Microbial Metabolite

• CAS Number:

  [6020-87-7]