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Sardomozide

CAT: 0804-HY-13746-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13746-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.
CAS Number
149400-88-4
Product Name Alternative
CGP 48664; SAM-486A
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Sardomozide.html
Purity
98.85
Solubility
10 mM in DMSO
Smiles
N=C(C1=CC=CC2=C1CC/C2=N\NC(N)=N)N
Molecular Formula
C11H14N6
Molecular Weight
230.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54 (12) :3210-7.|[2]Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58 (17) :3883-90.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
Metabolomics. 2025 Jun 14;21 (4) :82.|SSRN. 2024 Mar 14.|bioRxiv. 2024 Nov 17:2024.08.24.609500.|Cell Rep. 2025 Jan 28;44 (1) :115123.|Cell. 2020 Jun 11;181 (6) :1329-1345.e24.|mSystems. 2024 May 16;9 (5) :e0024624.|Preprints. 2025 May 22.|Sci Adv. 2023 May 19;9 (20) :eade0718.

Chemical Information

Sardomozide

Sardomozide is a small molecule drug. Sardomozide has a monoisotopic molecular weight of 230.13 Da.

CAS Number149400-88-4
PubChem CID9576789
IUPAC Name(1E)-1-(diaminomethylidenehydrazinylidene)-2,3-dihydroindene-4-carboximidamide
Molecular FormulaC11H14N6
Molecular Weight230.27
XLogP-0.3
Topological Polar Surface Area127
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count17
Formal Charge0
Complexity368
SMILES
C1C/C(=N\N=C(N)N)/C2=C1C(=CC=C2)C(=N)N
InChI
InChI=1S/C11H14N6/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17)/b16-9+
InChIKey
CYPGNVSXMAUSJY-CXUHLZMHSA-N
Chemical Structure
2D Structure
2D structure of Sardomozide
CAS: 149400-88-4
CID: 9576789
Formula: C11H14N6
MW: 230.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight230.27
XLogP3-0.3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass230.12799447
Monoisotopic Mass230.12799447
Topological Polar Surface Area127 Ų
Heavy Atom Count17
Formal Charge0
Complexity368
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T12833-01Sardomozide
B2566-5Sardomozide Hydrochloride
A22031-1Sardomozide 1mg
C01808-5mgSardomozide dihydrochloride
MBS3841301-01Sardomozide HCl
A22031-100Sardomozide 100mg
A22031-5Sardomozide 5mg
A22031-50Sardomozide 50mg
A22031-25Sardomozide 25mg
A22031-10Sardomozide 10mg

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