Ondansetron (hydrochloride dihydrate)

Ondansetron (hydrochloride dihydrate)

• CAS Number: 103639-04-9
• UNSPSC Description: Ondansetron (GR 38032) hydrochloride dehydrate is an orally active, highly selective and competitive 5-HT3 receptor antagonist (crosses the blood-brain barrier). Ondansetron hydrochloride dehydrate can be used in studies of preventing nausea and vomiting associated with cancer chemotherapy, radiation therapy and surgery[1][2].
• Target Antigen: 5-HT Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/Ondansetron-hydrochloride-dihydrate.html
• Purity: 99.94
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 16.67 mg/mL (ultrasonic)
• Smiles: O=C1C(CN2C=CN=C2C)CCC(N3C)=C1C4=C3C=CC=C4.[H]Cl.O.O
• Molecular Weight: 365.85
• References & Citations: [1]Yamamoto K, et al. Ondansetron, dexamethasone and an NK1 antagonist block radiation sickness in mice. Pharmacol Biochem Behav. 2005 Sep;82(1):24-9. |[2]Wilde MI, et al. Ondansetron. A review of its pharmacology and preliminary clinical findings in novel applications. Drugs. 1996 Nov;52(5):773-94. Eur J Pharm Sci. 2023 May 22;106475.|Int J Pharm. 2015 Dec 30;496(1):33-41.|Patent. US20170319486A1.|Front Pharmacol. 2024 Aug 21:15:1443169.|J Ethnopharmacol. 2024 Jan 5:117703.|Journal of Radiation Research and Applied Sciences. 2023 Dec, 16(4), 100682.|Prog Neuropsychopharmacol Biol Psychiatry. 2022 Nov 30;110689.|SSRN. 2023 Srep 5.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: Launched