Lanicemine

• Description :

  Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively) . Antidepressant effects[1].

• Product Name Alternative :

  AZD6765

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H320

• Target :

  IGluR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/lanicemine.html

• Purity :

  99.0

• Solubility :

  10 mM in DMSO

• Smiles :

  N[C@H](C1=CC=CC=C1)CC2=CC=CC=N2

• Molecular Formula :

  C13H14N2

• Molecular Weight :

  198.26

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations :

  [1]Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19 (9) :978-85.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  NMDA Receptor

• CAS Number :

  [153322-05-5]