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Lenumlostat (hydrochloride)

CAT: 0804-HY-107422ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-107422ASize:1 Each
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Description
PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively) . PAT-1251 Hydrochloride is used in the research of fibrotic diseases.
CAS Number
2098884-53-6
Product Name Alternative
PAT-1251 (hydrochloride) ; GB2064 (hydrochloride)
UNSPSC
12352005
Target
Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lenumlostat-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(OC2=NC(C(F)(F)F)=CC(CN)=C2)=C1)N3C[C@@H](F)[C@H](O)C3.Cl
Molecular Formula
C18H18ClF4N3O3
Molecular Weight
435.80
References & Citations
[1]Rowbottom MW, et al. Identification of 4- (Aminomethyl) -6- (trifluoromethyl) -2- (phenoxy) pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2) . J Med Chem. 2017 May 25;60 (10) :4403-4423.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
Cell Chem Biol. 2024 Jul 9:S2451-9456 (24) 00273-3.|In Vitro Model. 2025 Mar 7;4 (1) :59-69.

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C03589-100mgLenumlostat
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