GW3965

CAT: 0804-HY-10627-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-10627-02Size:10 mM - 1 mL

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Description

GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3].

CAS Number

405911-09-3

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

LXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/GW3965.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=C(C(F)(F)F)C=CC=C1CN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CCCOC4=CC(CC(O)=O)=CC=C4

Molecular Formula

C33H31ClF3NO3

Molecular Weight

582.05

Precautions

H302, H315, H319, H335

References & Citations

[1]Mitro, Nico., et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012), 60 (6), 616-621.|[2]Guo, Deliang., et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011), 1 (5), 442-456.|[3]Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117 (21), 5751-5761.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Chemical Information

3-(3-(((2-Chloro-3-(trifluoromethyl)phenyl)methyl)(2,2-diphenylethyl)amino)propoxy)benzeneacetic acid

GW 3965 is a diarylmethane.

CAS Number	405911-09-3
PubChem CID	447905
IUPAC Name	2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid
Molecular Formula	C33H31ClF3NO3
Molecular Weight	582.0
XLogP	5.9
Topological Polar Surface Area	49.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	13
Heavy Atom Count	41
Formal Charge	0
Complexity	753

SMILES

C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4

InChI

InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)

InChIKey

NAXSRXHZFIBFMI-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 405911-09-3

CID: 447905

Formula: C33H31ClF3NO3

MW: 582.0

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	582.0
XLogP3	5.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	13
Exact Mass	581.1944560
Monoisotopic Mass	581.1944560
Topological Polar Surface Area	49.8 Å²
Heavy Atom Count	41
Formal Charge	0
Complexity	753
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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MBS3840839-01	GW3965
522685	GW3965 HCl
A15100-25	GW3965 25mg
A15100-10	GW3965 10mg
M14397-01	GW3965 hydrochloride
GTR19220472-01	FITC-GW3965

GW3965

Chemical Information

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