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QF0301B

CAT: 0804-HY-101690-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101690-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
QF0301B is an α1 adrenergic receptor antagonist and a low α2 adrenoceptor, 5-HT2A, and histamine H1 receptor blocker.
CAS Number
149247-12-1
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/3,4-Dihydro-2-[2-[4-_2-methoxyphenyl_-1-piperazinyl]ethyl]-1_2H_-naphthalenone.html
Solubility
10 mM in DMSO
Smiles
O=C1C(CCN2CCN(C3=CC=CC=C3OC)CC2)CCC4=C1C=CC=C4
Molecular Formula
C23H28N2O2
Molecular Weight
364.48
References & Citations
[1]Orallo F, et al. In vivo and in vitro pharmacological studies of a new hypotensive compound (QF0301B) in rat: Comparison with prazosin, a known α1-adrenoceptor antagonist. Vascul Pharmacol. 2003 Feb;40 (2) :97-108.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; α adrenergic receptor

Chemical Information

2-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-3,4-dihydro-2H-naphthalen-1-one
CAS Number149247-12-1
PubChem CID10044334
IUPAC Name2-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-3,4-dihydro-2H-naphthalen-1-one
Molecular FormulaC23H28N2O2
Molecular Weight364.5
XLogP4
Topological Polar Surface Area32.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity489
SMILES
COC1=CC=CC=C1N2CCN(CC2)CCC3CCC4=CC=CC=C4C3=O
InChI
InChI=1S/C23H28N2O2/c1-27-22-9-5-4-8-21(22)25-16-14-24(15-17-25)13-12-19-11-10-18-6-2-3-7-20(18)23(19)26/h2-9,19H,10-17H2,1H3
InChIKey
PJOARVZMKMVACL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-3,4-dihydro-2H-naphthalen-1-one
CAS: 149247-12-1
CID: 10044334
Formula: C23H28N2O2
MW: 364.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight364.5
XLogP34
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass364.215078140
Monoisotopic Mass364.215078140
Topological Polar Surface Area32.8 Ų
Heavy Atom Count27
Formal Charge0
Complexity489
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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ZFA24712-01QF0301B
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A19856-1QF0301B 1mg
A19856-50QF0301B 50mg
A19856-10QF0301B 10mg

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