Ralfinamide (mesylate)

• Description:

  Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain[1][2].

• Product Name Alternative:

  FCE-26742A (mesylate)

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ralfinamide-mesylate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@H](NCC1=CC=C(OCC2=CC=CC=C2F)C=C1)C(N)=O.CS(=O)(O)=O

• Molecular Formula:

  C18H23FN2O5S

• Molecular Weight:

  398.45

• Precautions:

  P264-P270-P330-P405-P501

• References & Citations:

  [1]Zhang SH, et al. Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain. 2008 Oct 15;139 (2) :293-305.|[2]Liang X, et al. Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. Eur J Pharmacol. 2018 Mar 15;823:27-34.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 3

• CAS Number:

  202825-45-4